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What is Dimethocaine ?
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Other name: Larocaine,
IUPAC name: 3-Diethylamino-2,2-dimethylpropyl-4-aminobenzoate
CAS No.: 94-15-5
Appearance: white to yellowish crystalline powder
Molecular Weight: 278.39
Molecular Formula: C16H26N2O2
Purity: 99% min.
Package: 1kg/foil bag or according to the customers requirements.
Storage: Store in a cool dry place and keep away from direct strong light.
Use: Local anesthetics. BUY DIMETHOCAINE ONLINE
Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine. First of all it actually was explained that dimethocaine only has 10% of the potency because of cocaine, however customer reviews have proven it’s not correct, effects are stronger than expected. The effects act like the ones from cocaine, emotional state lift, euphoria and even stimulation, the results do not appear in a hurry like cocaine, on the other hand last longer.BUY DIMETHOCAINE ONLINE
There are a limited number of reports about the drug’s effects. Most point to little activity or, at most, mild euphoria and mild stimulation.Buy Dimethocaine Online
STIMULATION AND EUPHORIA OFFERED BY THE DRUG IS GENERALLY SAID TO BE WEAKER THAN WHAT’S OFFERED BY COCAINE OR AMPHETAMIne.
The local anesthetic effect generally leads to numbness in the nasal region when taken intranasally.
Some users have experienced fatigue and slight mental impairment when the effects dissipate and even a lasting CNS depressant effect into the following day.
However, the lack of experience reports makes it difficult to tell how common these after effects are.
It had a memory impairing effect in mice in a maze test. This was hypothesized in the paper to come from a dopamine mechanism.
Lidocaine, which lacks similar dopaminergic activity, didn’t have the same response.
Greater locomotor activity and cocaine-like behavior effects were observed in mice.
Anxiogenic effects were seen at 10 mg/kg and 20 mg/kg in a maze test in mice.
Dimethocaine had some apparent dose-dependent antinociceptive effects in mice, including in writhing and hot-plate tests.
Chemistry & Pharmacology
Dimethocaine has a structure that’s closer to procaine, a drug that lacks psychoactive effects, than cocaine.
A major difference is that it lacks a tropane ring.
It functions as a dopamine reuptake inhibitor.
The drug was only slightly less potent than cocaine for displacing mazindol at the dopamine transporter (DAT).
DA reuptake inhibition potency appears to go in this order: Cocaine > Dimethocaine > Tetracaine > Procaine > Chloroprocaine.
Dimethocaine elevated dopamine in the nucleus accumbens in rats.
EC500 (concentration for 500% basal level) in striatum
Cocaine: 15 uM
Dimethocaine: 57 uM
Procaine: 3.5 mM